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Electroporation

Transdermal delivery of drugs and non-pharmacological active ingredients has been utilized for decades. Initially in orthopedics for pain relief and rehabilitation, this method has extended to
dermatology and plastic surgery.

What is transdermal delivery?

Transdermal delivery or electroporation is an effective, non-invasive technique. It uses gentle electrical impulses to temporarily create “electropores” on the skin surface (invisible to the naked eye), making the skin permeable to active ingredients in cosmetics and medications.

How electroporation works

The goal of transdermal delivery is to act on cellular metabolism so that our target, a dermal cell called fibroblast, produces collagen, elastin, and other substances in adequate quantities.
The treatment harnesses the ability of specific electromagnetic waves to activate intracellular transport channels (electropores), through which it is possible to deliver the amino acids necessary for fibroblasts to produce the substances that the dermis requires.

In addition to antiaging treatments, electroporation is also used in the trichological field to toughen the bulb in defluvium (progressive and irreversible hair loss), in the treatment of acne and rosacea, or in preparation for blepharoplasty and facelift surgeries.

In anti-aging procedures, the treatment is carried out to provide the skin with all those amino acids necessary for the production of new substances in the extracellular matrix (collagen, hyaluronic acid, and elastin), while for the scalp, microelements such as sulfur-containing amino acids, specific growth factors, and minoxidil are delivered.

 

Procedure of electroporation

Sophisticated equipment is employed for electroporation. Treatment is administered with a special handpiece, allowing active ingredients to penetrate the dermis, the intermediate layer between the epidermis and hypodermis.

Transdermal delivery surpasses the tough outer layer of the epidermis (stratum corneum), which typically impedes penetration of hydrophilic substances with high molecular weights like hyaluronic acid and collagen.

Electroporation session

Sessions are outpatient and last about 40 minutes. The therapy is painless and does not require local anesthesia. Treatment frequency typically begins weekly, then extends to every 15 or 20 days as advised by the specialist.

Mild skin irritation may occur post-treatment but usually resolves within hours. Face and body electroporation can be performed at Medicalia Miami. Our procedures are performed by experienced dermatologists using certified and tested products. Equipped with state-of-the-art technology compliant with current regulations, our center ensures safe and effective dermatological procedures.

Bibliography
Gehl J. Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta
Physiol Scand. 2003 Apr;177(4):437-47. doi: 10.1046/j.1365-201X.2003.01093.x. PMID: 12648161.
Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal Drug Delivery: Innovative Pharmaceutical
Developments Based on Disruption of the Barrier Properties of the stratum corneum. Pharmaceutics.
2015;7(4):438-470. Published 2015 Oct 22. doi:10.3390/pharmaceutics7040438
In aesthetic dermatology, transdermal delivery is crucial for:
 
  • Fine wrinkles
  • Anti-aging
  • Facial and neck densification and firming
  • Acne e Rosacea
  • Skin Spots
  • Seborrhea
  • Cellulite
  • Adiposity
  • Body toning
  • Preparation for plastic surgery techniques.

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